Trials and Interventions to Improve Brain Health





The Systematic Multi-Domain Alzheimer's Risk Reduction (SMARRT) Trial is a pilot, randomized controlled trial designed to slow the rate of cognitive decline and delay or prevent Alzheimer's Disease. In the SMARRT intervention group, the team will work with participants to develop a personalized action plan to address risk reduction including cardiovascular risk management; smoking cessation; physical, mental and social activity; healthy diet; improved sleep quality and medication management. Dr. Yaffe is one of multiple PIs on this project while Dr. Barnes is a co-investigator.


Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI) iincorporates elements from Eastern and Western exercise modalities and is designed to build and maintain the capacity to perform basic functional movements while increasing mindful body awareness and enhancing social connection. Pilot study results suggest that PLIE is associated with meaningful improvements in physical function, cognitive function and quality of life in individuals with dementia, as well as reduced caregiver burden. The goal of the current study is to perform a randomized, controlled trial to test the efficacy of PLIE in older adults who have MCI but who do not yet have dementia. The investigators will also investigate the neural mechanisms underlying PLIE by acquiring brain imaging measures.



TeleGOALS Cognitive Training Study for Older Veterans with TBI, funded by VA Rehabilitation Research and Development, aims to adapt GOALS, an established group-format cognitive rehabilitation intervention for problems with executive function, for delivery to older Veterans with history of TBI via in-home video telehealth. 

 TeleGOALS Clinical Trials Website