Yue Leng, PhD

Core Faculty
[email protected]
+1 415 221-4810 ext. 26565

As an internationally-trained epidemiologist, Dr. Leng is interested in studying the link between sleep and neurodegeneration in older adults. Her research program, supported by an NIH K99/R00 award, focuses on the relationship between napping, sleep, circadian rhythms and risk of neurodegenerative diseases. Dr. Leng is also interested in developing behavioral sleep intervention programs in patients with mild cognitive impairment, with the ultimate aim of decreasing risk of Alzheimer’s onset or progression.

Publications: 

Causal Associations of Sleep Apnea with Alzheimer's Disease and Cardiovascular Disease: a Bidirectional Mendelian Randomization Analysis.

medRxiv : the preprint server for health sciences

Cavaillès C, Andrews SJ, Leng Y, Chatterjee A, Daghlas I, Yaffe K

Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.

medRxiv : the preprint server for health sciences

Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y

Associations of 24-hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Blackwell TL, Figueiro MG, Tranah GJ, Zeitzer JM, Yaffe K, Ancoli-Israel S, Kado DM, Ensrud KE, Lane NE, Leng Y, Stone KL, Osteoporotic Fractures in Men (MrOS) Study Group

Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults.

JAMA network open

Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, Yiallourou S, Bisson A, Himali D, Leng Y, Yang Q, Seshadri S, Beiser A, Gottesman RF, Redline S, Lopez O, Lutsey PL, Yaffe K, Stone KL, Purcell SM, Himali JJ

Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals.

Brain, behavior, and immunity

Ma YH, Shen LX, Li YZ, Leng Y, Yang L, Chen SD, He XY, Zhang YR, Chen RJ, Feng JF, Tan L, Dong Q, Suckling J, David Smith A, Cheng W, Yu JT

Multidimensional Sleep Health and Long-Term Cognitive Decline in Community-Dwelling Older Men.

Journal of Alzheimer's disease : JAD

Cavaillès C, Yaffe K, Blackwell T, Buysse D, Stone K, Leng Y

Race Differences in the Association Between Sleep Medication Use and Risk of Dementia.

Journal of Alzheimer's disease : JAD

Leng Y, Stone KL, Yaffe K

Cognitive and Functional Trajectories in Older Adults With Prediagnostic Parkinson Disease.

Neurology

Bock MA, Vittinghoff E, Bahorik AL, Leng Y, Fink H, Yaffe K

Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort.

Alzheimer's & dementia (Amsterdam, Netherlands)

Naismith SL, Leng Y, Palmer JR, Lucey BP

Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants.

Biological psychiatry

Yang L, Deng YT, Leng Y, Ou YN, Li YZ, Chen SD, He XY, Wu BS, Huang SY, Zhang YR, Kuo K, Feng W, Dong Q, Feng JF, Suckling J, Smith AD, Li F, Cheng W, Yu JT

Daytime napping and Alzheimer's dementia: A potential bidirectional relationship.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Li P, Gao L, Yu L, Zheng X, Ulsa MC, Yang HW, Gaba A, Yaffe K, Bennett DA, Buchman AS, Hu K, Leng Y

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.

International journal of epidemiology

Zheng J, Zhang Y, Rasheed H, Walker V, Sugawara Y, Li J, Leng Y, Elsworth B, Wootton RE, Fang S, Yang Q, Burgess S, Haycock PC, Borges MC, Cho Y, Carnegie R, Howell A, Robinson J, Thomas LF, Brumpton BM, Hveem K, Hallan S, Franceschini N, Morris AP, Köttgen A, Pattaro C, Wuttke M, Yamamoto M, Kashihara N, Akiyama M, Kanai M, Matsuda K, Kamatani Y, Okada Y, Walters R, Millwood IY, Chen Z, Davey Smith G, Barbour S, Yu C, Åsvold BO, Zhang H, Gaunt TR

Public Willingness and Determinants of COVID-19 Vaccination at the Initial Stage of Mass Vaccination in China.

Vaccines

Zhao YM, Liu L, Sun J, Yan W, Yuan K, Zheng YB, Lu ZA, Liu L, Ni SY, Su SZ, Zhu XM, Zeng N, Gong YM, Wu P, Ran MS, Leng Y, Shi J, Shi L, Lu L, Bao YP

Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures.

Sleep

Posner AB, Tranah GJ, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Leng Y, Zeitzer JM, Chen DM, Webber KR, Stone KL

Peripheral Clock System Abnormalities in Patients With Parkinson's Disease.

Frontiers in aging neuroscience

Li T, Cheng C, Jia C, Leng Y, Qian J, Yu H, Liu Y, Wang N, Yang Y, Al-Nusaif M, Le W

Current Alzheimer disease research highlights: evidence for novel risk factors.

Chinese medical journal

Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y

Sleep Timing and Risk of Dementia Among the Chinese Elderly in an Urban Community: The Shanghai Aging Study.

Frontiers in neurology

Li X, Ding D, Zhao Q, Wu W, Xiao Z, Luo J, Yaffe K, Leng Y

Grandparental care and sleep disturbances in preschool children: a population-based prospective cohort study.

Sleep medicine

Li W, Wang G, Yu Z, Ip P, Leng Y, Zhang Y, Zhao J, Zhang J, Jiang Y, Deng Y, Wu Y, Meng M, Zhu Q, Jiang F

Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans.

Neurology

Leng Y, Byers AL, Barnes DE, Peltz CB, Li Y, Yaffe K

Genetic risk of Alzheimer's disease and sleep duration in non-demented elders.

Annals of neurology

Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD

Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease.

JAMA neurology

Leng Y, Blackwell T, Cawthon PM, Ancoli-Israel S, Stone KL, Yaffe K

Corrigendum to: Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.

Sleep

Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C

Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.

Sleep

Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C

Multidimensional Sleep and Mortality in Older Adults: A Machine-Learning Comparison with Other Risk Factors.

The journals of gerontology. Series A, Biological sciences and medical sciences

Wallace ML, Buysse DJ, Redline S, Stone K, Ensrud K, Leng Y, Ancoli-Israel S, Hall MH

To nap or not to nap: more questions than answers.

Heart (British Cardiac Society)

Leng Y, Yaffe K

Connections Between Insomnia and Cognitive Aging.

Neuroscience bulletin

Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y

Objective napping, cognitive decline, and risk of cognitive impairment in older men.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K

Association between circadian rhythms and neurodegenerative diseases.

The Lancet. Neurology

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K

Mortality risk of loneliness in the oldest old over a 10-year follow-up.

Aging & mental health

Wang H, Leng Y, Zhao E, Fleming J, Brayne C

Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men.

International journal of epidemiology

Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K

Antidepressant Use and Cognitive Outcomes in Very Old Women.

The journals of gerontology. Series A, Biological sciences and medical sciences

Leng Y, Diem SJ, Stone KL, Yaffe K

Corrigendum to: "Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women".

The journals of gerontology. Series A, Biological sciences and medical sciences

Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K

Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women.

The journals of gerontology. Series A, Biological sciences and medical sciences

Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K

Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor?

Sleep medicine

Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT

Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population.

Nutrition, metabolism, and cardiovascular diseases : NMCD

Leng Y, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT

Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis.

Neurology

Leng Y, Cappuccio FP, Wainwright NW, Surtees PG, Luben R, Brayne C, Khaw KT

Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study.

BMJ open

Leng Y, Ahmadi-Abhari S, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT

Daytime napping and the risk of all-cause and cause-specific mortality: a 13-year follow-up of a British population.

American journal of epidemiology

Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT

Self-reported sleep patterns in a British population cohort.

Sleep medicine

Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Wareham N, Brayne C, Khaw KT

Epidemiology of esophageal cancer in Yanting - regional report of a national screening programme in China.

Asian Pacific journal of cancer prevention : APJCP

Wang X, Fan JC, Wang AR, Leng Y, Li J, Bao Y, Wang Y, Yang QF, Ren Y

The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study.

Psychological medicine

Leng Y, Wainwright NW, Hayat S, Stephan BC, Matthews FE, Luben R, Surtees PG, Khaw KT, Brayne C

Cervical cancer in Indigenous women: The case of Australia.

Maturitas

Shannon GD, Franco OH, Powles J, Leng Y, Pashayan N