Deborah Barnes, PhD

Core Faculty
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Dr. Barnes is internationally recognized as an expert in the epidemiology of dementia. There are currently more than 6 million Americans and 55 millions people worldwide living with Alzheimer's disease and related dementias, and prevalence is expected to more than double by 2050. Dr. Barnes' research is designed to minimize the impact of the impending dementia epidemic using a three-pronged approach: 1) identifying modifiable risk factors for cognitive impairment and dementia in older adults; 2) developing dementia prediction models that can be used to estimate the impact of risk factor reduction and to target interventions toward those who are at greatest risk; and 3) testing interventions to delay onset or slow progression of cognitive impairment and dementia.

Much of Dr. Barnes' early research focused on performing observational studies to identify factors associated with increased or decreased risk of cognitive decline and dementia. She is particularly interested in the potential protective effects of physical, mental and social activity, as well as the effects of chronic health conditions such as depression, diabetes and hypertension. Together, these studies suggest that many risk factors for dementia are modifiable or treatable, raising hope that risk reduction interventions could potentially lower risk of cognitive impairment and dementia in late life.

Another major focus of Dr. Barnes' work has been on development of dementia risk models to identify older adults at risk of dementia in different settings and to forecast the potential impact of risk reduction interventions. In 2011, Dr. Barnes and Dr. Kristine Yaffe published a landmark article in Lancet Neurology in which they estimated that 30 to 50% of Alzheimer's and dementia cases are potentially attributable to 7 modifiable risk factors--physical inactivity, low education, smoking, depression, diabetes, mid-life hypertension and mid-life obesity--and that relatively small reductions in these risk factors at a societal level could potentially prevent millions of cases from ever occurring. These findings have subsequently been replicated and extended by several other groups and serve as the foundation for public health policy worldwide to reduce dementia risk. They also recently collaborated on a 2022 update in JAMA Neurology.

Dr. Barnes' most recent research is focusing on performing randomized, controlled trials (RCTs) to test interventions for delaying onset or slowing progression of dementia-related symptoms. With colleagues Dr. Wolf Mehling and Dr. Margaret Chesney, she led the development of a novel, mind-body, group movement program for people living with dementia call Preventing Loss of Independence through Exercise (PLIÉ). PLIÉ combines training procedural ("muscle") memory for basic daily movements, present-moment body awareness, and social connection through group movement. Dr. Barnes' research has found that PLIÉ has physical, cognitive, social and emotional benefits in people with subjective cognitive decline, mild cognitive impairment, and mild to moderate dementia in community, adult day and nursing home settings. Dr. Barnes' colleagues are currently studying implementation of a PLIÉ staff training program in VA nursing homes. In addition, Dr. Barnes co-founded a company called Together Senior Health to commercialize an online version of PLIÉ called Moving Together, and they are also studying a dementia risk reduction program called Brain Health Together.

Finally, Dr. Barnes is collaborating with Dr. Sascha Dublin at Kaiser Permanente Washington to improve detection and diagnosis of dementia in primary care. They developed and validated eRADAR (electronic health record Risk of Alzheimer's and Dementia Assessment Rule), which uses health record data to help identify patients who may have undiagnosed dementia. They are currently performing an embedded, pragmatic clinical trial of eRADAR to determine whether implementation of targeted screening improves diagnosis and patient care.

Publications: 

Quality and Satisfaction With Advance Care Planning Conversations Among English- and Spanish-Speaking Older Adults.

Journal of palliative medicine

Gelfman LP, Barnes DE, Goldstein N, Volow AM, Shi Y, Li B, Sudore RL

Telehealth delivery of group-format cognitive rehabilitation to older veterans with TBI: a mixed-methods pilot study.

Applied neuropsychology. Adult

Kornblith E, Schweizer S, Abrams G, Gardner R, Barnes D, Yaffe K, Novakovic-Agopian T

Partnering to cope with pain: A pilot study of a caregiver-assisted pain coping skills intervention for patients with cognitive impairment and dementia.

Palliative & supportive care

Porter LS, Weiner DK, Ramos K, Barnes DE, Schmader KE, Gwyther L, Ritchie CS, Keefe FJ

Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia.

JAMA internal medicine

Deardorff WJ, Barnes DE, Jeon SY, Boscardin WJ, Langa KM, Covinsky KE, Mitchell SL, Whitlock EL, Smith AK, Lee SJ

PREPARE for your care and easy-to-read advance directives increase real-time goal concordant care.

Journal of the American Geriatrics Society

Rennels CF, Barnes DE, Volow A, Shi Y, Li B, Sudore RL

TBI and risk of death in military veterans over 14 years: Injury severity, timing, and cause of death.

Journal of psychiatric research

Byers AL, Li Y, Barnes DE, Boscardin WJ, Peltz CB, Yaffe K

Physical Therapist Telehealth Delivery at 1 Year Into COVID-19.

Physical therapy

Miller MJ, Pak SS, Keller DR, Gustavson AM, Barnes DE

External Validation of the eRADAR Risk Score for Detecting Undiagnosed Dementia in Two Real-World Healthcare Systems.

Journal of general internal medicine

Coley RY, Smith JJ, Karliner L, Idu AE, Lee SJ, Fuller S, Lam R, Barnes DE, Dublin S

Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US.

JAMA neurology

Nianogo RA, Rosenwohl-Mack A, Yaffe K, Carrasco A, Hoffmann CM, Barnes DE

Association of Race and Ethnicity With Incidence of Dementia Among Older Adults.

JAMA

Kornblith E, Bahorik A, Boscardin WJ, Xia F, Barnes DE, Yaffe K

Post-amputation cognitive impairment is related to worse perceived physical function among middle age and older prosthesis users.

Archives of physical medicine and rehabilitation

Miller MJ, Hoffman RM, Swink LA, Barnes DE, Christiansen CL

Clinical features of dementia cases ascertained by ICD coding in LIMBIC-CENC multicenter study of mild traumatic brain injury.

Brain injury

Walker WC, O'Rourke J, Wilde EA, Pugh MJ, Kenney K, Dismuke-Greer CL, Ou Z, Presson AP, Werner JK, Kean J, Barnes D, Karmarkar A, Yaffe K, Cifu D

Remote Assessment of Cardiovascular Risk Factors and Cognition in Middle-Aged and Older Adults: Proof-of-Concept Study.

JMIR formative research

Eastman JA, Kaup AR, Bahorik AL, Butcher X, Attarha M, Marcus GM, Pletcher MJ, Olgin JE, Barnes DE, Yaffe K

Traumatic brain injury, cardiovascular disease, and risk of dementia among older US Veterans.

Brain injury

Kornblith E, Bahorik A, Li Y, Peltz CB, Barnes DE, Yaffe K

Surrogate Decision Makers Need Better Preparation for Their Role: Advice from Experienced Surrogates.

Journal of palliative medicine

Bakke BM, Feuz MA, McMahan RD, Barnes DE, Li B, Volow AM, Powell J, Sudore RL

Importance of Accounting for Regional Differences in Modifiable Risk Factors for Alzheimer's Disease and Related Dementias: The Case for Tailored Interventions.

Journal of Alzheimer's disease : JAD

Hoffmann CM, Nianogo RA, Yaffe K, Rosenwohl-Mack A, Carrasco A, Barnes DE

The Effect of Sex and Wealth on Population Attributable Risk Factors for Dementia in South Africa.

Frontiers in neurology

Bobrow K, Hoang T, Barnes DE, Gardner RC, Allen IE, Yaffe K

Empowering patients with the PREPARE advance care planning program results in reciprocal clinician communication.

Journal of the American Geriatrics Society

Nouri S, Street RL, Barnes DE, Shi Y, Volow AM, Li B, Alexander SC, Sudore RL

Implementation of an integrative movement program for residents with dementia in a VA nursing home.

BMC geriatrics

Akram A, Nicosia F, Lee J, Lee M, Martin L, Martinez S, Ordoñez C, Woo M, Barnes DE

Patient and caregiver perspectives on a tool to increase recognition of undiagnosed dementia: a qualitative study.

BMC geriatrics

Palazzo L, Hsu C, Barnes DE, Gray MF, Greenwood-Hickman MA, Larson EB, Dublin S

Physical inactivity in older adults with cognitive impairment without dementia: room for improvement.

Aging clinical and experimental research

Miller MJ, Cenzer I, Barnes DE, Covinsky KE

Engaging Diverse Older Adults With Cognitive Impairment and Caregivers in Advance Care Planning: A Pilot Study of the Interactive PREPARE Website.

Alzheimer disease and associated disorders

Kotwal AA, Barnes DE, Volow AM, Li BH, Boscardin WJ, Sudore RL

Meaningful Activities and Sources of Meaning for Community-Dwelling People Living with Dementia.

Journal of the American Medical Directors Association

Allison TA, Gubner JM, Oh A, Harrison KL, Pham K, Barnes DE, Johnson JK, Covinsky KE, Smith AK

Guys and dolls: Two case reports of spontaneous interactions with dolls in male veterans with dementia.

Psychological services

Malinowski SD, Nicosia F, Mehling W, Woodstock R, Barnes DE

The PREPARE for Your Care program increases advance care planning engagement among diverse older adults with cancer.

Cancer

Nouri SS, Barnes DE, Shi Y, Volow AM, Shirsat N, Kinderman AL, Harris HA, Sudore RL

English and Spanish-speaking vulnerable older adults report many barriers to advance care planning.

Journal of the American Geriatrics Society

Phung LH, Barnes DE, Volow AM, Li BH, Shirsat NR, Sudore RL

Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era.

JAMA neurology

Martinez S, Yaffe K, Li Y, Byers AL, Peltz CB, Barnes DE

Engagement in Meaningful Activities Among Older Adults With Disability, Dementia, and Depression.

JAMA internal medicine

Oh A, Gan S, Boscardin WJ, Allison TA, Barnes DE, Covinsky KE, Smith AK

Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans.

Neurology

Leng Y, Byers AL, Barnes DE, Peltz CB, Li Y, Yaffe K

Preventing Loss of Independence through Exercise (PLIÉ): A Pilot Trial in Older Adults with Subjective Memory Decline and Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD

Chao LL, Lee JA, Martinez S, Barlow C, Chesney MA, Mehling WE, Barnes DE

Anxious, Depressed, and Planning for the Future: Advance Care Planning in Diverse Older Adults.

Journal of the American Geriatrics Society

McMahan RD, Barnes DE, Ritchie CS, Jin C, Shi Y, David D, Walker EJ, Tang VL, Sudore RL

Building a National Program for Pilot Studies of Embedded Pragmatic Clinical Trials in Dementia Care.

Journal of the American Geriatrics Society

Brody AA, Barnes DE, Chodosh J, Galvin JE, Hepburn KW, Troxel AB, Hom K, McCarthy EP, Unroe KT

Empowering Older Adults to Discuss Advance Care Planning During Clinical Visits: The PREPARE Randomized Trial.

Journal of the American Geriatrics Society

Freytag J, Street RL, Barnes DE, Shi Y, Volow AM, Shim JK, Alexander SC, Sudore RL

Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus.

Journal of Alzheimer's disease : JAD

Anstey KJ, Peters R, Zheng L, Barnes DE, Brayne C, Brodaty H, Chalmers J, Clare L, Dixon RA, Dodge H, Lautenschlager NT, Middleton L, Qiu C, Rees G, Shahar S, Yaffe K

A national study of TBI and risk of suicide and unintended death by overdose and firearms.

Brain injury

Byers AL, Li Y, Barnes DE, Seal KH, Boscardin WJ, Yaffe K

Military Sexual Trauma in Older Women Veterans: Prevalence and Comorbidities.

Journal of general internal medicine

Gibson CJ, Maguen S, Xia F, Barnes DE, Peltz CB, Yaffe K

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia.

Journal of the American Geriatrics Society

Barnes DE, Zhou J, Walker RL, Larson EB, Lee SJ, Boscardin WJ, Marcum ZA, Dublin S

Brief English and Spanish Survey Detects Change in Response to Advance Care Planning Interventions.

Journal of pain and symptom management

Shi Y, Barnes DE, Boscardin J, You JJ, Heyland DK, Volow AM, Howard M, Sudore RL

Health Literacy Matters More Than Experience for Advance Care Planning Knowledge Among Older Adults.

Journal of the American Geriatrics Society

Nouri SS, Barnes DE, Volow AM, McMahan RD, Kushel M, Jin C, Boscardin J, Sudore RL

Recovery-Oriented Outcomes Associated with Long-Acting Injectable Antipsychotics in an Urban Safety-Net Population.

Community mental health journal

Yoshimatsu K, Elser A, Thomas M, Dilley J, Barnes D, Ballinger A, Wozniak S, Mangurian C

Leadership, Inside and Out: The Tideswell-AGS-ADGAP Emerging Leaders in Aging Program.

Journal of the American Geriatrics Society

Chang A, Lundebjerg NE, Abrams J, Barnes DE, Fain MJ, Hall WJ, Johnson TM, Michael Harper G, Williams B, Ritchie CS

Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol.

Journal of Alzheimer's disease : JAD

Yaffe K, Barnes DE, Rosenberg D, Dublin S, Kaup AR, Ludman EJ, Vittinghoff E, Peltz CB, Renz AD, Adams KJ, Larson EB

Ten-Year Prevalence of Cognitive Impairment Diagnoses and Associated Medical and Psychiatric Conditions in a National Cohort of Older Female Veterans.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Lwi SJ, Barnes DE, Xia F, Peltz C, Hoang T, Yaffe K

Military-related risk factors in female veterans and risk of dementia.

Neurology

Yaffe K, Lwi SJ, Hoang TD, Xia F, Barnes DE, Maguen S, Peltz CB

Engaging Diverse English- and Spanish-Speaking Older Adults in Advance Care Planning: The PREPARE Randomized Clinical Trial.

JAMA internal medicine

Sudore RL, Schillinger D, Katen MT, Shi Y, Boscardin WJ, Osua S, Barnes DE

Cognition and Incarceration: Cognitive Impairment and Its Associated Outcomes in Older Adults in Jail.

Journal of the American Geriatrics Society

Ahalt C, Stijacic-Cenzer I, Miller BL, Rosen HJ, Barnes DE, Williams BA

Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans.

JAMA neurology

Barnes DE, Byers AL, Gardner RC, Seal KH, Boscardin WJ, Yaffe K

Patient Activation: A Key Component of Successful Advance Care Planning.

Journal of palliative medicine

David D, Barnes DE, McMahan RD, Shi Y, Katen MT, Sudore RL

Improving A Full Range of Advance Care Planning Behavior Change and Action Domains: the PREPARE Randomized Trial.

Journal of pain and symptom management

Lum HD, Barnes DE, Katen MT, Shi Y, Boscardin J, Sudore RL

Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study.

Neurology

Gardner RC, Byers AL, Barnes DE, Li Y, Boscardin J, Yaffe K

Traumatic Brain Injury and Receipt of Prescription Opioid Therapy for Chronic Pain in Iraq and Afghanistan Veterans: Do Clinical Practice Guidelines Matter?

The journal of pain : official journal of the American Pain Society

Seal KH, Bertenthal D, Barnes DE, Byers AL, Gibson CJ, Yaffe K

A Cohort Study of Healthcare Utilization in Older Adults with Undiagnosed Dementia.

Journal of general internal medicine

Lee SJ, Larson EB, Dublin S, Walker R, Marcum Z, Barnes D

Veterans Group Exercise: A randomized pilot trial of an Integrative Exercise program for veterans with posttraumatic stress.

Journal of affective disorders

Goldstein LA, Mehling WE, Metzler TJ, Cohen BE, Barnes DE, Choucroun GJ, Silver A, Talbot LS, Maguen S, Hlavin JA, Chesney MA, Neylan TC

A 12-week integrative exercise program improves self-reported mindfulness and interoceptive awareness in war veterans with posttraumatic stress symptoms.

Journal of clinical psychology

Mehling WE, Chesney MA, Metzler TJ, Goldstein LA, Maguen S, Geronimo C, Agcaoili G, Barnes DE, Hlavin JA, Neylan TC

The Mental Activity and eXercise (MAX) trial: Effects on physical function and quality of life among older adults with cognitive complaints.

Contemporary clinical trials

Middleton LE, Ventura MI, Santos-Modesitt W, Poelke G, Yaffe K, Barnes DE

Advance Care Planning Documentation Practices and Accessibility in the Electronic Health Record: Implications for Patient Safety.

Journal of pain and symptom management

Walker E, McMahan R, Barnes D, Katen M, Lamas D, Sudore R

Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP).

International psychogeriatrics

Anstey KJ, Peters R, Clare L, Lautenschlager NT, Dodge HH, Barnes DE, Shahar S, Brodaty H, Rees G

Association of Traumatic Brain Injury With Chronic Pain in Iraq and Afghanistan Veterans: Effect of Comorbid Mental Health Conditions.

Archives of physical medicine and rehabilitation

Seal KH, Bertenthal D, Barnes DE, Byers AL, Strigo I, Yaffe K

Measuring Advance Care Planning: Optimizing the Advance Care Planning Engagement Survey.

Journal of pain and symptom management

Sudore RL, Heyland DK, Barnes DE, Howard M, Fassbender K, Robinson CA, Boscardin J, You JJ

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease.

Annals of neurology

Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS

A pilot study to evaluate multi-dimensional effects of dance for people with Parkinson's disease.

Contemporary clinical trials

Ventura MI, Barnes DE, Ross JM, Lanni KE, Sigvardt KA, Disbrow EA

Lifetime alcohol use and cognitive performance in older adults.

Journal of addictive diseases

Kalapatapu RK, Ventura MI, Barnes DE

Improving advance care planning for English-speaking and Spanish-speaking older adults: study protocol for the PREPARE randomised controlled trial.

BMJ open

Sudore RL, Barnes DE, Le GM, Ramos R, Osua SJ, Richardson SA, Boscardin J, Schillinger D

Post-traumatic stress disorder symptoms and associated health and social vulnerabilities in older jail inmates.

Aging & mental health

Flatt JD, Williams BA, Barnes D, Goldenson J, Ahalt C

Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women.

The journals of gerontology. Series A, Biological sciences and medical sciences

Barbour KE, Lui LY, McCulloch CE, Ensrud KE, Cawthon PM, Yaffe K, Barnes DE, Fredman L, Newman AB, Cummings SR, Cauley JA

Implementation of an Interdisciplinary, Team-Based Complex Care Support Health Care Model at an Academic Medical Center: Impact on Health Care Utilization and Quality of Life.

PloS one

Ritchie C, Andersen R, Eng J, Garrigues SK, Intinarelli G, Kao H, Kawahara S, Patel K, Sapiro L, Thibault A, Tunick E, Barnes DE

Implications of Risk Factors for Alzheimer's Disease in Canada's Indigenous Population.

Canadian geriatrics journal : CGJ

MacDonald JP, Barnes DE, Middleton LE

Leisure activities and depressive symptoms in older adults with cognitive complaints.

International psychogeriatrics

Poelke G, Ventura MI, Byers AL, Yaffe K, Sudore R, Barnes DE

Patients optimizing epilepsy management via an online community: the POEM Study.

Neurology

Hixson JD, Barnes D, Parko K, Durgin T, Van Bebber S, Graham A, Wicks P

Preventing loss of independence through exercise (PLIÉ): a pilot clinical trial in older adults with dementia.

PloS one

Barnes DE, Mehling W, Wu E, Beristianos M, Yaffe K, Skultety K, Chesney MA

Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity.

JAMA neurology

Gardner RC, Burke JF, Nettiksimmons J, Kaup A, Barnes DE, Yaffe K

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data.

The Lancet. Neurology

Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C

Traumatic brain injury and risk of dementia in older veterans.

Neurology

Barnes DE, Kaup A, Kirby KA, Byers AL, Diaz-Arrastia R, Yaffe K

Lifestyle and health-related risk factors and risk of cognitive aging among older veterans.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Yaffe K, Hoang TD, Byers AL, Barnes DE, Friedl KE

Prisoner of war status, posttraumatic stress disorder, and dementia in older veterans.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Meziab O, Kirby KA, Williams B, Yaffe K, Byers AL, Barnes DE

Alcohol consumption patterns and cognitive impairment in older women.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Hoang TD, Byers AL, Barnes DE, Yaffe K

Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging.

Journal of geriatric psychiatry and neurology

Goveas JS, Espeland MA, Hogan PE, Tindle HA, Shih RA, Kotchen JM, Robinson JG, Barnes DE, Resnick SM

A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Barnes DE, Cenzer IS, Yaffe K, Ritchie CS, Lee SJ

Development and validation of a brief dementia screening indicator for primary care.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Barnes DE, Beiser AS, Lee A, Langa KM, Koyama A, Preis SR, Neuhaus J, McCammon RJ, Yaffe K, Seshadri S, Haan MN, Weir DR

Cognitive outcomes after psychotherapeutic interventions for major depression in older adults with executive dysfunction.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Mackin RS, Nelson JC, Delucchi K, Raue P, Byers A, Barnes D, Satre DD, Yaffe K, Alexopoulos GS, Arean PA

Posttraumatic stress disorder and cognitive function: findings from the mind your heart study.

The Journal of clinical psychiatry

Cohen BE, Neylan TC, Yaffe K, Samuelson KW, Li Y, Barnes DE

Midlife risk score for the prediction of dementia four decades later.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA

Development and validation of a questionnaire to detect behavior change in multiple advance care planning behaviors.

PloS one

Sudore RL, Stewart AL, Knight SJ, McMahan RD, Feuz M, Miao Y, Barnes DE

A novel website to prepare diverse older adults for decision making and advance care planning: a pilot study.

Journal of pain and symptom management

Sudore RL, Knight SJ, McMahan RD, Feuz M, Farrell D, Miao Y, Barnes DE

Physical activity and risk of cognitive impairment among oldest-old women.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Wang S, Luo X, Barnes D, Sano M, Yaffe K

The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults.

JAMA internal medicine

Barnes DE, Santos-Modesitt W, Poelke G, Kramer AF, Castro C, Middleton LE, Yaffe K

Recovery, dependence or death after discharge.

Journal of general internal medicine

Barnes DE, Boscardin WJ, Landefeld CS

Prediction of recovery, dependence or death in elders who become disabled during hospitalization.

Journal of general internal medicine

Barnes DE, Mehta KM, Boscardin WJ, Fortinsky RH, Palmer RM, Kirby KA, Landefeld CS

Dysthymia and depression increase risk of dementia and mortality among older veterans.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Byers AL, Covinsky KE, Barnes DE, Yaffe K

Acute care for elders units produced shorter hospital stays at lower cost while maintaining patients' functional status.

Health affairs (Project Hope)

Barnes DE, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J, Chren MM, Landefeld CS

Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia.

Archives of general psychiatry

Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA

Predicting Alzheimer's risk: why and how?

Alzheimer's research & therapy

Barnes DE, Lee SJ

Activity energy expenditure and incident cognitive impairment in older adults.

Archives of internal medicine

Middleton LE, Manini TM, Simonsick EM, Harris TB, Barnes DE, Tylavsky F, Brach JS, Everhart JE, Yaffe K

Physical activity over the life course and its association with cognitive performance and impairment in old age.

Journal of the American Geriatrics Society

Middleton LE, Barnes DE, Lui LY, Yaffe K

Posttraumatic stress disorder and risk of dementia among US veterans.

Archives of general psychiatry

Yaffe K, Vittinghoff E, Lindquist K, Barnes D, Covinsky KE, Neylan T, Kluse M, Marmar C

The effect of maintaining cognition on risk of disability and death.

Journal of the American Geriatrics Society

Yaffe K, Lindquist K, Vittinghoff E, Barnes D, Simonsick EM, Newman A, Satterfield S, Rosano C, Rubin SM, Ayonayon HN, Harris T

Commentary on "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Dementia risk indices: A framework for identifying individuals with a high dementia risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K

Developing a national strategy to prevent dementia: Leon Thal Symposium 2009.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, Buckholtz N, Carrillo M, Ferris S, Greenberg BD, Grundman M, Khachaturian AS, Kuller LH, Lopez OL, Maruff P, Mohs RC, Morrison-Bogorad M, Phelps C, Reiman E, Sabbagh M, Sano M, Schneider LS, Siemers E, Tariot P, Touchon J, Vellas B, Bain LJ

Secondhand smoke, vascular disease, and dementia incidence: findings from the cardiovascular health cognition study.

American journal of epidemiology

Barnes DE, Haight TJ, Mehta KM, Carlson MC, Kuller LH, Tager IB

Predicting dementia: role of dementia risk indices.

Future neurology

Barnes DE, Yaffe K

Depressed mood is not a risk factor for incident dementia in a community-based cohort.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Becker JT, Chang YF, Lopez OL, Dew MA, Sweet RA, Barnes D, Yaffe K, Young J, Kuller L, Reynolds CF

Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial.

Alzheimer disease and associated disorders

Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, Kramer JH

Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia.

International journal of geriatric psychiatry

Edwards ER, Spira AP, Barnes DE, Yaffe K

Predicting risk of dementia in older adults: The late-life dementia risk index.

Neurology

Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K

Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Cauley JA, Lui LY, Barnes D, Ensrud KE, Zmuda JM, Hillier TA, Hochberg MC, Schwartz AV, Yaffe K, Cummings SR, Newman AB

Cognition in older women: the importance of daytime movement.

Journal of the American Geriatrics Society

Barnes DE, Blackwell T, Stone KL, Goldman SE, Hillier T, Yaffe K

Race/ethnic differences in AD survival in US Alzheimer's Disease Centers.

Neurology

Mehta KM, Yaffe K, Pérez-Stable EJ, Stewart A, Barnes D, Kurland BF, Miller BL

An advance directive redesigned to meet the literacy level of most adults: a randomized trial.

Patient education and counseling

Sudore RL, Landefeld CS, Barnes DE, Lindquist K, Williams BA, Brody R, Schillinger D

Preclinical cognitive decline and subsequent sleep disturbance in older women.

Neurology

Yaffe K, Blackwell T, Barnes DE, Ancoli-Israel S, Stone KL

Women who maintain optimal cognitive function into old age.

Journal of the American Geriatrics Society

Barnes DE, Cauley JA, Lui LY, Fink HA, McCulloch C, Stone KL, Yaffe K

Physical activity and dementia: The need for prevention trials.

Exercise and sport sciences reviews

Barnes DE, Whitmer RA, Yaffe K

Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort.

Neurobiology of aging

Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx B, Satterfield S, Harris T, Cummings SR

Use of a modified informed consent process among vulnerable patients: a descriptive study.

Journal of general internal medicine

Sudore RL, Landefeld CS, Williams BA, Barnes DE, Lindquist K, Schillinger D

Caregiver characteristics are associated with neuropsychiatric symptoms of dementia.

Journal of the American Geriatrics Society

Sink KM, Covinsky KE, Barnes DE, Newcomer RJ, Yaffe K

Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study.

Archives of general psychiatry

Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K

Vitamin E and donepezil for the treatment of mild cognitive impairment.

The New England journal of medicine

Barnes DE, Yaffe K

The relationship between literacy and cognition in well-educated elders.

The journals of gerontology. Series A, Biological sciences and medical sciences

Barnes DE, Tager IB, Satariano WA, Yaffe K

A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults.

Journal of the American Geriatrics Society

Barnes DE, Yaffe K, Satariano WA, Tager IB

A prospective study of physical activity and cognitive decline in elderly women: women who walk.

Archives of internal medicine

Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K

Environmental tobacco smoke. The Brown and Williamson documents.

JAMA

Barnes DE, Hanauer P, Slade J, Bero LA, Glantz SA

Nicotine and addiction. The Brown and Williamson documents.

JAMA

Slade J, Bero LA, Hanauer P, Barnes DE, Glantz SA

Estimation of haloperidol concentrations in rat striatum after chronic treatment.

Brain research bulletin

Bellows EP, Barnes DE, Csernansky JG

Sensitization versus tolerance to haloperidol-induced catalepsy: multiple determinants.

Pharmacology, biochemistry, and behavior

Barnes DE, Robinson B, Csernansky JG, Bellows EP