Novel Dementia Risk Factors Over the Life Course



Predictors of Mid-life and 5-year Changes in Cognitive Function, an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) Study, seeks to determine the relationship between cardiovascular risk factors (CVRF)s in young adulthood and risk of cognitive impairment at mid-life among participants followed over 25 years.

The Study of Osteoporotic Fractures is a longitudinal cohort study which has followed community-dwelling women aged 65 and older since 1986. While SOF’s original goal was to understand risk factors for osteoporotic fractures, the study has evolved over time and now focuses on determinants of successful aging, including measures of cognitive performance.

The Health, Aging and Body Composition Study is an interdisciplinary study focused on identifying risk factors for the decline of function in healthier older adults, particularly related to changes in body composition with age. The study was designed to address differences in onset of functional limitation, disability and longevity between older men and women as well as between Blacks and Whites. 

Healthy Heart, Healthy Brain: A Pooled Life-course Cohort for Dementia Risk Assessment (HARMONY)  The Harmony Study aims to provide improved estimates of age-specific exposures to cardiovascular risk factors over the life-course on Alzheimer's Disease (AD) and cognitive outcomes associated with aging. Pooling four biracial prospective cohorts which together span the adult life-course, will enable us to determine the type and timing of exposures that influence cognitive decline and risk of AD and other dementia, in addition to how modifications of these exposures may reduce the burden of cognitive decline and AD, as well as racial and gender disparities.