This study, published in the January 26, 2022 online version of Neurology, studied 2,653 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) Study (57% women, 46% Black). Echocardiograms were obtained at Years 5, 25 and 30 visits (participant mean age 30, 50 and 55 years) to assess left ventricular (LV) mass (LVMi); LV systolic function with LV ejection fraction (LVEF); LV diastolic function with left atrial volume (LAVi) and early peak mitral velocity (E)/early peak mitral annular velocity (e’) ratio. At Year 30, five cognitive domains were measured: global cognition, processing speed, executive function, delayed verbal memory, and verbal fluency. We investigated the association between midlife (Year 30) and 25-year change in cardiac structure and function on midlife cognition using linear regressions.

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