Study: Cardiac structure & function and midlife cognition

This study, published in the January 26, 2022 online version of Neurology, studied 2,653 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) Study (57% women, 46% Black). Echocardiograms were obtained at Years 5, 25 and 30 visits (participant mean age 30, 50 and 55 years) to assess left ventricular (LV) mass (LVMi); LV systolic function with LV ejection fraction (LVEF); LV diastolic function with left atrial volume (LAVi) and early peak mitral velocity (E)/early peak mitral annular velocity (e’) ratio. At Year 30, five cognitive domains were measured: global cognition, processing speed, executive function, delayed verbal memory, and verbal fluency. We investigated the association between midlife (Year 30) and 25-year change in cardiac structure and function on midlife cognition using linear regressions.

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